Breaking down bacterial communication: a review of quorum quenching agents

Abstract Background Bacterial cells communicate via small extracellular molecules that facilitate gene expression which is dependent on cell density and this mechanism known as Quorum Sensing (QS). At low density, these bacteria show a single cellular type of behavior but once they reach the threshold level alter to multicellular hence QS established by transfer signalling called autoinducers. sensing inhibitors (QSI) are those hinder quorum pathway. Main body abstract The emergence antimicrobial resistance has become threat mankind with being one mechanisms responsible for resistance. Hence Quenching can be considered interrupt bacterial communication. This review focuses effects different synthetic natural quorum-sensing organisms how it affects their regulation. Conclusion Different agents quench various mechanistic pathways. against both Gram-positive Gram-negative provide wider scope prevent emerging